We discover and utilize novel chemical probes in genetically engineered mouse (GEM) models of cancer, various functional genomic approaches including genome-wide CRISPR knockout screens, and epigenomic technologies such as RNA- Seq, ChIP-Seq, CUT&RUN and ATAC-Seq.
We plan to expand our efforts in identifying novel therapeutic targets in genetically defined tumors. Recently, we have discovered and patented novel proteolysis targeting chimeric molecules (PROTACs) that induce selective degradation of oncoproteins and received grants to further develop these molecules as cancer therapeutics. Excitingly, some of our chemical probes have synergistic anti-tumor efficacy in combination with immunotherapy.
The positions will provide deep exposure and training in cancer functional genomics, chromatin biology, cancer immunology and cancer drug discovery and can be geared to the individuals career goals.
We seek highly motivated individuals with a Ph.D. or equivalent degree in immunology, genetics or molecular & cell biology. Experience with tumor immune profiling and hands on mice work is required.
The Lissanu laboratory is a well-funded lab situated in a highly dynamic and stimulatory environment for learning. MD Anderson Cancer Center is rated number one hospital in cancer care in the United States. The institute offers active graduate and postdoctoral training programs and the unmatched scientific environment of the Texas Medical Center, the world's largest biomedical center. Competitive salary and benefits are provided to post-doctoral fellows. Houston is the fourth largest city in the USA with a vibrant and booming economy. Houston has a mild winters and is sunny year round.
Responsibilities:
• Use cutting-edge approaches to seek novel therapeutic targets for human cancers
• Be responsible for the design and execution of experimental work, data analysis and write up
• Attend and present at internal and international meetings
• Be expected to publish data in top scientific journals
Job requirements:
• PhD or equivalent in Immunology, Molecular Biology, Biochemistry, Genetics or related field
• Good publication record
• Excellent communication skills are required.
Please send a cover letter, curriculum vitae, names and contact information of three references, and a brief summary of past research accomplishments and future research plans to: Yonathan Lissanu, M.D, Ph.D. (ylissanu@mdanderson.org)
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